Medicina Alternativă: fiziologie clinică şi metode de tratament 2010; Vol. 15: 16-23


Summary

Evaluation of the ability of certain natural resources to counteract lipid oxidation in vitro

V. Rudic, L. Cepoi, L. Rudi, T. Chiriac, V. Miscu, A. Cojocari, D. Sadovnic, V. Ciuhrii


The article presents the study on the influence of extracts from biomass of cianobacteria Spirulina platensis, micro-alga Porphyridium cruentum and insect Lymantria dispar on the oxidation process of low density lipoproteins (LDL). Maximal levels of LDL inhibition for Spirulina and Porphyridium extracts were 65-69%. At the same time, preparations from the insect showed 98% inhibition. In these cases, the least amount of malondialdehyde (MDA) has been received, which is a marker of oxidative stress, associated with numerous pathological states of the organism. Extracts, obtained with 10-95% ethanol from biomass of Spirulina and Porphyridium, inhibit LDL oxidation relatively evenly. It is an evidence of a wide range of antioxidant substances, which were extracted in polar media in our experiments. Water-alcoholic 20% extracts from biomass of Lymantria larvae differ by their exclusive ability to inhibit the process of LDL oxidation. This finding is promising for biotechnology and pharmacology in the area of development and production of аnti-inflammatory and normolipidemic medication.

Keywords
antioxidant activity, low density lipoproteins, Spirulina platensis, Porphyridium cruentum, Lymantria dispar, malondialdehyde

 
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